姓名：张玉静

照片：

 职称：副教授 

 简介：

张玉静，博士，校聘副教授，硕士生导师，重点实验室副主任，主要从事环境化学物诱导肝毒性损伤的分子毒理学研究。担任湖南省预防医学会营养学委员会理事。

教育经历：

2014.09-2017.06中南大学公共卫生学院 公共卫生与预防医学

2011.09-2014.06中山大学公共卫生学院 卫生毒理学

2006.09-2011.06青岛大学公共卫生学院 预防医学

科研文章：

1.Yujing Zhang, Gang Yang, Shuai Huang, Xinyue Yang, Fengyan Yuan, Sulai Liu, Xing Yu, Reg ulation of Cr(VI)-induced Premature Senescence in L02 Hepatocytes by ROS-Ca2+- NF-κB Signaling, Oxidative medicine and cellular longevity, 2022, 2022.

2.Yujing Zhang, Shuai Huang, Gang Yang, Lianhogn Zou, Xin Huang, Sulai Liu, The Role of miRNAs during Endoplasmic Reticulum Stress Induced Apoptosis in Digestive Cancer, Journal of Cancer, 2021,12(22):6787-6795.

3.Yujing Zhang,Shuai Huang, Shiyi Tan, Mingke Chen, Shang Yang, Shi Chen, 3-methyadenine inhibits lipopolysaccharides-induced pulmonary inflammation at the early stage of silicosis via blocking NF-κB signaling pathway, Toxicology and Industrial Health, 2021.

4.Yujing Zhang,Yu Ma, Yuanyuan Xiao, Chan Lu, Fang Xiao, Drp1-dependent mitochondrial fission contributes to Cr(VI)-induced mitophagy and hepatotoxicity, Ecotoxicology and Environmental Safety, 2020, 203:110928.

5.Yujing Zhang,Huanfeng Bian, Yu Ma, Yuanyuan Xiao, Fang Xiao, Cr(VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes. Biochemical Journal, 2020, 477(14):2607-2619.

6. Yu Ma#,Yujing Zhang#, Yuanyuan Xiao, Fang Xiao, Increased Mitochondrial Fragmentation Mediated by Dynamin-Related Protein 1 Contributes to Hexavalent Chromium-Induced Mitochondrial Respiratory Chain Complex I-Dependent Cytotoxicity, Toxics. 2020, 8(3):E50.

7.Yujing Zhang, Yu Ma, Ningjuan Liang, Yuehui Liang, Chan Lu, Fang Xiao, ROS-mediated miR-21-5p regulates the proliferation and apoptosis of Cr(VI)-exposed L02 hepatocytes via targeting PDCD4, Ecotoxicology and Environmental Safety, 2020,191:110160.

8.Yujing Zhang, Yu Ma, Ningjuan Liang, Yuehui Liang, Chan Lu, Fang Xiao, Blockage of ROS-ERK-DLP1 signaling and mitochondrial fission alleviates Cr(VI)-induced mitochondrial dysfunction in L02 hepatocytes. Ecotoxicology and Environmental Safety, 2019, 186:109749.

9.Yujing Zhang,Yiyuan Zhang, Yuanyuan Xiao, Caigao Zhong, Fang Xiao, High expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K/AKT pathway, Ecotoxicology and Environmental Safety, 2019 ,183:109465.

10.Yujing Zhang, Fang Xiao, Xinmin Liu, Kaihua Liu, Xiaoxin Zhou, Caigao Zhong, Cr(VI) induces cytotoxicity in vitro through activation of ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction via the PI3K/Akt signaling pathway, Toxicology in Vitro, 2017, 41: 232-234.

11.Yujing Zhang, Yiyuan Zhang, Caigao Zhong, Fang Xiao, Cr(VI) induces premature senescence through ROS-mediated p53 pathway in L-02 hepatocytes, Scientific Reports, 2016, 6: 34578.

12. Xin Huang, Zuodong Li, Jun Lei, Dapeng Wang,Yujing Zhang(通讯作者), Genetic polymorphism in DGCR8 is associated with late onset of preeclampsia, BMC Pregnancy and Childbirth, 2019, 20(1):151.

13.Fengyan Yuan, Yiyuan Yang, Huiqin Zhou, Jing Quan, Chongyang Liu, Yi Wang,Yujing Zhang(通讯作者), Xing Yu, Heparanase in cancer progression: Structure, substrate recognition and therapeutic potential, Frontiers in Chemistry, 2022,10:926353.

14. Xing Yu, Jing Quan, Shuai Chen, Xinyue Yang, Shuai Huang, Gang Yang,Yujing Zhang^#.A protocol for Rapid Construction of Senescent CellsFront Integr Neurosci, 2022,16:929788.

15.张玉静,蒋妮,柳强,朱勇飞,黄昕.线粒体损伤在镉诱导肝细胞凋亡和DNA损伤中的作用[J].卫生研 究,2020,49(02):290-297.

16.张玉静,钟才高,环境内分泌干扰物的肝毒性作用研究进展.中国药理学与毒理学杂 志,32(6):484-489.

17.张玉静,钟才高,钙离子依赖的内质网应激在细胞凋亡中作用研究进展,中国职业医学, 2017, 44(03): 365-370.

18.张玉静,陈慧峰,廖昆,夏斌,殷花,何承勇,林育纯,林忠宁,镉对肝细胞中PPP2R1A启动子 区甲基化及其转录水平的影响,中国职业医学, 2014, 41(05): 496-501.

科研项目：

1.国家自然科学基金青年基金项目，81803272，miR-21在Cr(Ⅵ)诱导内质网应激反应性肝细胞凋亡中的作用及其机制研究，2019/01-2021/12，21万元，主持。

2.湖南省自然科学基金青年基金项目，2020JJ5385，PERK在长期低剂量Cr(Ⅵ)暴露诱导肝细胞早 熟性衰老中的作用及机制研究，2020/01-2022/12，5万元，主持。

3.湖南省卫健委,一般项目, 202212045173, RCN1/PERK信号通路在Cr(Ⅵ)致肝细胞早衰中的作用及机制研究, 2022-01至2024-12, 4万元,主持。

4.湖南省教育厅一般项目，19C1155，基于PERK/ Nrf2信号通路探讨Cr(Ⅵ)诱导肝细胞早衰的内 质网应激机制，2019/10-2022/09，2万元，主持。

5.3522集团的新网站科学研究启动基金，[Cr(VI)]诱导肝细胞早衰的价值研究，2018/05-2020/05，3万元，主持。

专利：

ZL202110265256.5一种血吸虫虫卵检测滤膜的制作装置。(排名第二)

指导学生：

1.湖南省大学生创新性训练项目，2项

2.全国大学生生命科学竞赛，国家三等奖、湖南赛区二等奖

3.3522集团的新网站优秀本科毕业论文，1项

联系方式：18163683079

zhangyujing@hunnu.edu.cn；zhangyujing24@163.com