名字:何祖平
照片:
职称:二级教授
职务:3522集团的新网站院长
研究生招生专业:基础医学(博士学位);病理学与病理生理学(硕士学位)
联系电话:0731-88912446(Office)
电子邮箱:zupinghe@hunnu.edu.cn
简介:
何祖平教授,3522集团的新网站院长,湖南省二级教授,“潇湘学者”特聘教授,博士生导师。湖湘高层次人才聚焦工程-杰出创新人才、上海高校特聘教授(东方学者)。“模式动物与干细胞生物学”湖南省重点实验室主任、“生殖与转化医学”湖南省工程研究中心主任。曾任上海市男科学研究所所长、上海市生殖医学重点实验室副主任。主持国家自然科学基金重点项目、国家重点研发计划课题、国家重大科学研究课题(2项)、国家自然科学基金面上项目(4项)、湖南省重大专项课题、湖南省重点研发计划项目、上海市科委重点项目、湖南省教育厅重点项目。“临床医学”国家一流专业建设点负责人,“基础医学”湖南省“十四五”重点学科建设负责人,“湖南省工人先锋号”团队带头人。2003年7月,在中国科学院研究生院获得博士学位。留美博士后和助理教授:2004年2月-2008年2月在美国乔治城大学从事博士后研究;2008年3月-2011年2月在美国乔治城大学担任助理教授。2011年2月为“海外高层次人才”引进到上海交通大学3522集团的新网站工作。2011年2月-2017年10为上海交通大学研究员,特聘教授,博士生导师。
国家杰出青年科学基金评审专家,长江学者(特聘教授、讲座教授、青年学者)评审专家,科技创新领军人才评审专家。国家重点研发计划项目、国家自然科学基金重大项目、重点项目、国际合作重点项目、面上项目、青年项目的通讯评审专家和/或会议评审专家。国家优秀青年基金(国内、海外)评审专家。湖南省“百人计划”会评专家。上海市自然科学奖主审专家(通讯评审、会议评审)。
长期从事生殖医学、细胞生物学与分子生物学研究。其研究成果已发表或接受发表在国际著名期刊,如Cell Death and Differentiation(IF:15.828)、Research (IF:11.0,2篇研究论文)、Molecular Therapy-Nucleic Acids (IF:10.18,6篇研究论文)、Cell Death and Disease(IF:9.685)、Stem Cell Reports(IF:7.765,2篇研究论文)、Stem Cells (IF:7.74,3篇研究论文)等。他以通讯作者或第一作者已发表发表SCI收录论文86篇,合计SCI影响因子(IF)>410;IF>5的论文42篇,IF>10的研究论文10篇。论文被Nature Genetics、Cell Stem Cell等SCI引用3700多次。单篇论文最高SCI引用365次。担任SCI期刊Frontiers in Cell and Developmental Biology副主编、Asian Journal of Andrology编委。获得湖南省自然科学奖二等奖(排名第一)、教育部科技进步奖二等奖、上海市医学科技奖一等奖。
社会(学术)兼职:
1.“模式动物与干细胞生物学”湖南省重点实验室主任
2.“生殖与转化医学”湖南省工程研究中心主任
3.上海市生殖医学重点实验室学术委员会委员
4.“危重医学代谢组学”湖南省重点实验室学术委员会副主任委员
5.“动物肠道功能调控”湖南省重点实验室学术委员会副主任委员
6.“湖南省动物肠道生态与健康”国际创新合作基地学术委员会副主任委员
7.“模式动物与干细胞生物学”湖南省重点实验室学术委员会委员
8.“生殖与转化医学”湖南省工程研究中心专家技术委员会委员
9.“小分子靶向药物研究与创制”湖南省重点实验室学术委员会委员
10.“分子流行病学”湖南省重点实验室学术委员会委员
11.避孕节育(生殖健康)新技术国家地方联合工程实验室学术委员会委员
12.中国生理学学会生殖科学专业委员会委员
13.中国动物学会生殖生物学分会理事
14.国际生殖研究学会(SSR)成员委员会委员
15.高等教育学会医学教育专委会理事
16.湖南省教育指导委员会医学专业委员会副主任委员
17.湖南医学教育科技学会副主任委员
18.Frontiers in Cell and Developmental Biology副主编
19.Asian Journal of Andrology编委
获得的人才项目(荣誉):
1.湖湘高层次人才聚集工程-杰出创新人才,2018年,100万元。
2.上海市教委-上海交通大学3522集团的新网站高峰学科计划(双百人计划),2015年,100万元。
3.上海高校特聘教授(东方学者),2012年,200万元。
4.上海市浦江人才计划,2011年,20万元。
主持的科研项目:
1.国家自然科学基金重点项目,人精原干细胞自我更新与分化为精子细胞的分子机理研究,2013/01-2017/12,280万元,项目负责人。
2.国家自然科学基金面上项目,人类支持细胞重编程为精原干细胞及其分化为有功能的精子细胞的分子机制研究,2022/01-2025/12,58万元,项目负责人。
3.国家自然科学基金面上项目,PAK1调控人类精原干细胞自我更新与凋亡的作用及分子机制研究,2019/01-2022/12,60万元,项目负责人。
4.国家自然科学基金面上项目,非编码小RNA调控正常与异常人精原干细胞自我更新与分化的作用及其机制研究,2017/01-2020/12,60万元,项目负责人。
5.国家自然科学基金面上项目,人精原干细胞诱导分化为成熟肝细胞及其信号转导的研究,2012/01-2015/12,55万元,项目负责人。
6.国家重点研发计划,精子发生成熟障碍的表观遗传机制,2016/04-2021/06,557万元,课题负责人。
7.国家重大科学研究计划,减数分裂调控因子的筛查,2013/04-2014/08,248万元,课题负责人。
8.国家重大科学研究计划,精原干细胞命运决定的表观遗传调控,2014/08-2018/08,95.8万元,子课题负责人。
9.湖南省重大专项课题,生殖细胞异常导致出生缺陷的机制研究,2019/10-2023/03,190万元,课题负责人。
10.湖南省重点研发计划项目,重大生殖疾病人源化动物模型的研究,2020/10-2022/09,50万元,项目负责人。
11.湖南省教育厅优势特色学科重点项目,发育中的干细胞研究,2022/06-2024/06,70万元,项目负责人。
12.3522集团的新网站“生殖健康与转化医学”创新团队,2023/07-2026/06,60万元,项目负责人。
13.上海市科委重点项目,microRNA对人类精原干细胞生成精子的调控作用及其机制,2013/01-2015/12,40万元,项目负责人。
代表性学术论文(以通讯作者或第一作者已发表SCI收录论文85篇,合计IF>400,*为通讯作者,#为第一作者):
1. Min Sun, Qingqing Yuan, Minghui Niu, Hong Wang, Liping Wen, Chencheng Yao, Jingmei Hou, Zheng Chen, Hongyong Fu, Fan Zhou, Chong Li, Shaorong Gao, Wei-Qiang Gao, Zheng Li,Zuping He*. Efficient Generation of Functional Haploid Spermatids From Human Germline Stem Cells by Three-Dimensional Induced System.Cell Death and Differentiation,2018, 25: 747-764. IF: 15.828
2. Yinghong Cui, Wei Chen, Li Du,Zuping He*. OIP5 interacts with NCK2 to mediate human spermatogonial stem cell self-renewal and apoptosisthrough cell cyclins and cycle progression and its abnormality is correlated with male infertility.Research, 2023, 6: 0162. IF: 11.0
3. Hong Wang, Ji Liu, Xiaojun Zhu, Bing Yang*,Zuping He*, Xudong Yao*.AZGP1P2/UBA1/RBM15 Cascade Mediates the Fate Determinations of Prostate Cancer Stem Cells and Promotes Therapeutic Effect of Docetaxel in Castration-Resistant Prostate Cancer via TPM1 m6A Modification.Research, 2023, 6:0252.IF: 11.0
4. Hong Wang, Qingqing Yuan, MinghuiNiu, Wnihui Zhang, Liping Wen, Hongyong Fu, Fan Zhou,Zuping He*.Transcriptional regulation of P63 on the apoptosis of male germ cells and three stages of spermatogenesis in mice.Cell Death and Disease, 2018, 9(2):76. IF :9.685
5. Wei Chen, Yinghong Cui, Bang Liu, Chunyun Li, Li Du, Ruiling Tang, Lulu Qin, Yiqun Jiang, Jian Li, Xing Yu, Quanyuan He,Zuping He*.Hsa-miR-1908-3p Mediates the Self-Renewal and Apoptosis of Human Spermatogonial Stem Cells via Targeting KLF2,Molecular Therapy-Nucleic Acids, 2020, 20: 788-800.IF:10.18
6. Hongyong Fu, Wenhui Zhang, Qingqing Yuan, MinghuiNiu, Fan Zhou, QianqianQiu, Guoping Mao, Hong Wang, Liping Wen, Min Sun, Zheng Li,Zuping He*.PAK1 Promotes the Proliferation and Inhibits Apoptosis of Human Spermatogonial Stem Cells via PDK1/KDR/ZNF367 and ERK1/2 and AKT Pathways.Molecular Therapy-Nucleic Acid, 2018, 12: 769-786.IF:10.18
7. Hongyong Fu, Fan Zhou, Qingqing Yuan, Wenhui Zhang, QianqianQiu, Xing Yu,Zuping He*.MiRNA-31-5p Mediates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells via Targeting JAZF1 and Cyclin A2.Molecular Therapy-Nucleic Acid,2018, 14: 90-100.IF :10.18
8. Fan Zhou, Qingqing Yuan, Wenhui Zhang, MinghuiNiu, Hongyong Fu, QainqianQiu, Guiping Mao, Hong Wang, Liping Wen, Mujun Lu, Zheng Li,Zuping He*.MiR-663a Stimulates Proliferation and Suppresses Early Apoptosis of Human Spermatogonial Stem Cells by Targeting NFIX and Regulating Cell Cycle.Molecular Therapy-Nucleic Acid, 2018, 12: 319-336.IF :10.18
9. Chencheng Yao, Qingqing Yuan, MinghuiNiu, Hongyong Fu, Fan Zhou, Wenhui Zhang, Hong Wang, Liping Wen, Ligang Wu, Zheng Li*,Zuping He*.Distinct expression profiles and novel targets of microRNAs in human spermatogonia, pachytene spermatocytes and round spermatids between OA patients and NOA patients.Molecular Therapy-Nucleic Acids, 2017, 9: 182-194. IF :10.18
10. Wei Liu,Li Du, Yinghong Cui,CaimeiHe,Zuping He*.WNT5Aregulates the proliferation, apoptosis and stemness of human stem Leydig cells via the β-catenin signaling pathway.Cellular and Molecular Life Sciences, 2024,81(1):93. IF :9.26
11.Wei Chen,Yinghong Cui,Chunyun Li,Caimei He,Li Du,Wei Liu,Zuping He*.KLF2 controls proliferation and apoptosis of human spermatogonial stem cells via targeting GJA1.iScience, 2024 Jan 26;27(2):109024.IF :6.1
12. Wenhui Zhang, Wei Chen, Yinghong Cui, Liping Wen, Qingqing Yuan, Fan Zhou, Qianqian Qiu, Min Sun, Liping Wen, Zheng Li,Zuping He*Direct reprogramming of human Sertoli cells into male germline stem cells with the selfrenewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes,StemCellReports,2021, 16:2798-2812.IF: 7.765
13. Li Du, Wei Chen, Chunyun Li, Yinghong Cui,Zuping He*.RNF144B stimulates the proliferation and inhibits the apoptosis of human spermatogonial stem cells via the FCER2/NOTCH2/HES1 pathway and its abnormality is associated with azoospermia.Journal of Cellular Physiology,2022, 237(9):3565-3577. IF :6.51
14.Yinghong Cui,Mingqing Zhou,Quanyuan He,Zuping He*.Zbtb40Deficiency Leads to Morphological and Phenotypic Abnormalities of Spermatocytes and Spermatozoa and Causes Male Infertility.Cells, 2023, 12(9):1264.IF :7.666
15.Cailin Wan,Wei Chen,Yinghong Cui,Zuping He*.MAP4K4/JNK Signaling Pathway Stimulates Proliferation and Suppresses Apoptosis of Human Spermatogonial Stem Cells and Lower Level of MAP4K4 Is Associated with Male Infertility.Cells, 2022, 11(23):3807. IF :7.666
16.Si Wu,Zixin Cheng,Ye Peng,Ying Cao,Zuping He*. GPx3 knockdown inhibits the proliferation and DNA synthesis and enhances the early apoptosis of human spermatogonial stem cells via mediating CXCL10 and cyclin B1.Frontiers in Cell and Developmental Biology, 2023,11:1213684.IF : 6.684
17. Bang Liu, Yinghong Cui, Wei Chen, Li Du, Chunyun Li, Cailin Wan,Zuping He*.Hsa-miR-100-3p Controls the Proliferation and DNA Synthesis and the Apoptosis of Human Sertoli Cells by Binding to SGK3.Frontiers in Cell and Developmental Biology, 2021,9:642916.IF : 6.684
18. Shi Yang, Ping Ping, Meng Ma, Peng Li, Ruhui Tian, Hao Yang, Yang Liu, Yuehua Gong, Zhenzhen Zhang, Zheng Li*,Zuping He*. Generation of haploid spermatids with fertilization and development capacity from human spermatogonial stem cells of cryptorchid patients.Stem Cell Report, 2014, 3(4): 663-675. IF: 7.765
19. Meng Ma, Shi Yang, Zhenzhen Zhang, Peng Li, Yuehua Gong, Linhong Liu, Yong Zhu, Ruhui Tian, Yufei Liu, Xiaobo Wang, Feng Liu, Lin He, Yang Liu, Hao Yang, Zheng Li*,Zuping He*.Sertoli cells from non-obstructive azoospermia and obstructive azoospermia patients show distinct morphology, raman spectrum and biochemical phenotype.Human Reproduction, 2013, 28(7):1863-1673.IF:6.918
20. Rui Zhou, Jingrouzi Wu, Bang Liu,Yiqun Jiang, Wei Chen, Jian Li, Quanyuan He,Zuping He*.The roles and mechanisms of Leydig cells and myoid cells in regulating spermatogenesis.Cellular and Molecular Life Sciences, 2019,76, 2681-2696. IF: 9.261
21. Wei Chen, Yinghong Cu, Minqi Ning, Haorui Zhang, Chenjun Yin,Zuping He*.The mechanisms and functions of microRNAs in mediating the fate determinations of human spermatogonial stem cells and Sertoli cells.Seminars in Cell and Developmental Biology,2022, 121: 32-39. IF:7.727
22. Li Du, Wei Chen,Zixin Cheng, Si Wu, Jian He, Lu Han,Zuping He*, Wenbing Qin*. Novel Gene Regulation in Normal and Abnormal Spermatogenesis.Cells, 2021,10(3):666. IF:7.666
23. Hao Yang, Yang Liu, Yanan Hai, Yuehua Gong, Ying Guo, Shi Yang, Zhenzhen Zhang, Linhong Liu, Zheng Li, Wei-Qiang Gao,Zuping He*.Efficient conversion of mouse spermatogonial stem cells to phenotypic and functional dopaminergic neurons via PI3K/Akt and P21/Smurf2/Nolz1 pathway.Molecular Neurobiology,2015, 52(3):1654-1669.IF: 6.19
24.Fan Zhou,Wei Chen,Yinghong Cui,Bang Liu,Qingqing Yuan,Zheng Li,Zuping He*.miRNA-122-5p stimulates the proliferation and DNA synthesis and inhibits the early apoptosis of human spermatogonial stem cells by targeting CBL and competing with lncRNA CASC7.Aging, 2021,12:25528-25546. IF: 5.682
25. QianqianQiu, Xing Yu, Chencheng Yao, YujunHao, Liqing Fan, Chunyi Li, Peng Xu,Geng An, Zheng Li,Zuping He*. FOXP3 pathogenic variants cause male infertility through affecting the proliferation and apoptosis of human spermatogonial stem cells.Aging, 2019, 11:12581-12599. IF: 5.682
26. Yanan Hai, Yun Liu, Jingmei Hou, Zhen Chen,Zuping He*. The roles and regulation of Sertoli cells in spermatogenesis.Seminars in Cell and Developmental Biology, 2014, 29:66-75. IF:7.727
27. Ying Guo, Yanan Hai, Chencheng Yao, Zheng Chen, JingmeiHou, Zheng Li,Zuping He*. Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation.Cell Communication and Signaling, 2015, 13: 20.
IF:7. 525
28. Zhenzhen Zhang, Yuehua Gong, Ying Guo, Yanan Hai, Hao Yang, Shi Yang, Yang Liu, Meng Ma, Linhong Liu, Zheng Li, Wei-Qiang Gao,Zuping He*. Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling, pathways and the inactivation of cyclin A, cyclin B and cyclin E.Cell Signaling and Communications, 2013, 11:67. IF:7.525
29. Chao Yang, ChenchengYao, Ruhui Tian, Zijue Zhu, LiangyuZhao, Peng Li, Huixing Chen, Yuhua Huang, ErleiZhi, Yuehua Gong, YunjingXue, Hong Wang, Qingqing Yuan,Zuping He*, Zheng Li*. miR-202-3p Regulates Sertoli Cell Proliferation, Synthesis Function, and Apoptosis by Targeting LRP6 and Cyclin D1 of Wnt/β-Catenin Signaling.Molecular Therapy-Nucleic Acids, 2018,14: 1-19.IF :10.18
30.Ruhui Tian,Chencheng Yao,Chao Yang,Zijue Zhu,Chong Li,Erlei Zhi,Junlong Wang,Peng Li,Huixing Chen,Qingqing Yuan,Zuping He*,Zheng Li*.Fibroblast growth factor-5 promotes spermatogonial stem cell proliferation via ERK and AKT activation.Stem Cell Research and Therapy, 2019, 10(1):40.IF : 6.832
31.Dai Zhou,Jingyu Fan,Zhizhong Liu,Ruiling Tang,Xingming Wang,Hao Bo,Fang Zhu,Xueheng Zhao,Zenghui Huang,Liu Xing,Ke Tao,Han Zhang,Hongchuan Nie,Huan Zhang,Wenbing Zhu,Zuping He*,Liqing Fan*. TCF3 Regulates the Proliferation and Apoptosis of Human Spermatogonial Stem Cells by Targeting PODXL.Frontiers in Cell and Developmental Biology, 2021,9: 695545. IF : 6.684
32.Mei Peng,Jintao Wu,Weifan Wang,Tianlong Liao,Simeng Xu,Di Xiao,Zuping He*,Xiaoping Yang*.Alpha-tocopherol enhances spermatogonial stem cell proliferation and restores mouse spermatogenesis by up-regulating BMI1. 2023, 10:1141964. IF : 6.59
33.Fang Zhu,Yang Luo,Hao Bo,Guanghui Gong,Ruiling Tang,Jingyu Fan,Huan Zhang,Gang Liu,Wenbing Zhu,Yueqiu Tan,Zuping He*,Liqing Fan*.Trace the profile and function of circular RNAs in Sertoli cell only syndrome.Genomics, 2021, 113:1845-1854. IF: 5.736
34.Mingqing Zhou,Yinghong Cui,Shanru Zuo,Qiyao Peng,Yucong Liu,Xueguang Li,Yide Yang,Quanze He,Xing Yu,Junhua Zhou,Zuping He*,Quanyuan He. ZBTB40 is a telomere-associated protein and protects telomeres in human ALT cells.Journal of Biological Chemistry, 2023, 299(9):105053.IF: 5.486
35.Z He#*,M Feng*. Activation, isolation, identification and culture of hepatic stem cells from porcine liver tissues.Cell Proliferation, 2011, 44(6):558-566.IF:8.5
36.Zuping He#, Jiji Jiang, Maria Kokkinaki, Lin Tang, Wenxian Zeng, Ian Gallicano, Ina Dobrinski, Martin Dym. MiRNA-20 and MiRNA-106a Regulate Spermatogonial Stem Cell Renewal at the Post-Transcriptional Level via Targeting STAT3 and Ccnd1 2.Stem Cells, 2013, 31(10): 2205-2217. IF: 7.74
37.Zuping He#, Jiji Jiang, Maria Kokkinaki, Martin Dym. Nodal signaling via an autocrine pathway is required for proliferation of mouse spermatogonial stem/progenitor cells through smad2/3 and Oct-4 activation.Stem Cells,2009,27: 2580-2590.IF: 7.74
38.Zuping He#, Jiji Jiang, Maria Kokkinaki, NadyGolestaneh, Marie-Claude Hofmann, Martin Dym. Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation.Stem Cells,2008, 26:266-278.IF: 7.74
39.ZP He#,WQ Tan,YF Tang,HJ Zhang,MF Feng. Activation, isolation, identification and in vitro proliferation of oval cells from adult rat livers.Cell Proliferation, 2004, 37(2):177-187.IF:8.5
科研获奖:
1.湖南省自然科学奖二等奖,项目:人类精原干细胞自我更新与分化为精子细胞的分子机制研究。第一完成人:何祖平。
2.教育部科技进步奖二等奖,项目:精子发生障碍诊疗关键技术构建及其临床应用。第二完成人:何祖平。
国家发明专利(已授权):
1.一种分离人精原干细胞的方法,专利号:ZL201110321182.9,何祖平,李铮,刘阳,刘建芳等。
2.一种人精原干细胞体外分化为功能精子细胞的三维诱导方法。专利号:ZL201610648584.2,何祖平,孙敏,袁青青,牛明辉,王洪,文丽平,付红勇,周帆,李铮。
博士生、硕士生、博士后培养:
1. 在上海交通大学培养博士研究生7名,毕业博士研究生7名;培养硕士研究生4名,毕业硕士研究生4名;指导博士后4名,出站博士后4名。博士研究生导师考核结果为优秀。
2. 在3522集团的新网站培养博士研究生6名、硕士研究生8名,毕业博士研究生1名,毕业硕士研究生3名;指导博士后2名、访问学者1名。