名字：李涛

照片：

职称：副教授

专业：免疫学学位点，再生医学和损伤修复

电子邮箱：63665116@qq.com

通讯地址：3522集团的新网站免疫学教研室

简介：

受教育经历

2002.9-2008.7，北京大学，医学部基础3522集团的新网站生物化学与分子生物学系，硕博连读，获理学博士学位

1997.9-2002.7，北京大学，医学部基础3522集团的新网站，基础医学专业本科，获医学学士学位

研究工作经历

2017.2-至今，3522集团的新网站，3522集团的新网站检验系，副教授

2012.9-2017.2，浙江师范大学，化学与生命科学学院，副教授

2008.7-2012.9，浙江师范大学，化学与生命科学学院，讲师

主持或参加科研项目（课题）及人才计划项目情况

1.国家自然科学基金面上项目，81870201，干细胞心肌程序分化中HDAC1、EZH2的阶段特异性效应及其成因，2019.01-2022.12，57万，主持

2.国家自然科学基金面上项目，31470082，发育期心脏感应环境胁迫的Nkx2.5蛋白剪切机制研究，2015.01-2016.12，30万，主持

3.国家自然科学基金青年基金，31101057，心肌程序分化过程中MSK、RSK激酶阶段特异性效应及机制的研究，2012.01-2014.12，25万，主持

代表性学术论文：

1.Li T, He Z, Zhang X, Tian M, Jiang K, Cheng G, Wang Y. The status of MAPK cascades contributes to the induction and activation of Gata4 and Nkx2.5 during the stepwise process of cardiac differentiation. Cell Signal. 2019 Feb;54:17-26.

2.Li T, Zhang X, Jiang K, Liu J, Liu Z. Dural effects of oxidative stress on cardiomyogenesis via Gata4 transcription and protein ubiquitination. Cell Death Dis. 2018 Feb 14;9(2):246.

3.Chen Y, Huang Q, Zhou H, Wang Y, Hu X, Li T. Inhibition of canonical WNT/β-catenin signaling is involved in leflunomide (LEF)-mediated cytotoxic effects on renal carcinoma cells. Oncotarget.2016 Aug 2;7(31):50401-50416.

4.Yu Z, Li T, Wang C, Deng S, Zhang B, Huo X, Zhang B, Wang X, Zhong Y, Ma X. Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells. Oncotarget.2016 Mar 29;7(13):15725-37.

5.Li P, Sun X, Ma Z, Liu Y, Jin Y, Ge R, Hao L, Ma Y, Han S, Sun H, Zhang M, Li R, Li T, Shen L. Transcriptional Reactivation of OTX2, RX1 and SIX3 during Reprogramming Contributes to the Generation of RPE Cells from Human iPSCs. INT J BIOL SCI . 2016 Feb 20;12(5):505-17.

6.Liu Y, Li P, Liu K, He Q, Han S, Sun X, Li T, Shen L. Timely inhibition of Notch signaling by DAPT promotes cardiac differentiation of murine pluripotent stem cells. PLOS ONE.2014 Oct 14; 9(10):e109588. DOI: 10.1371/journal.pone.0109588

7.Liu Z, Li T, Jiang K, Huang Q, Chen Y, Qian F. Induction of Chemoresistance by All-Trans Retinoic Acid via a Noncanonical Signaling in Multiple Myeloma Cells. PLOS ONE. 2014 Jan 9;9(1):e85571 DOI: 10.1371/journal.pone.0085571

8.Li T, Liu Z, Jiang K, Ruan Q. Angiopoietin2 Enhances Doxorubin Resistance in HepG2 cells by Upregulating Survivin and Ref-1 via MSK1 activation.Cancer Lett. 2013, 337(2):276-84.

9.Li T, Liu Z, Hu X, Ma K, Zhou C. Involvement of ERK-RSK cascade in phenylephrine-induced phosphorylation of GATA4.Biochim Biophys Acta - Molecular Cell Research. 2012, 1823(2):582-92.

10.Hu X, Li T, Zhang C, Liu Y, Xu M, Wang W, Jia Z, Ma K, Zhang Y, Zhou C. GATA4 regulates ANF expression synergistically with Sp1 in a cardiac hypertrophy model. J Cell Mol Med.2011 Sep;15(9):1865-77.

11.Liu Z, Li T, Liu Y, Jia Z, Li Y, Zhang C, Chen P, Ma K, Affara N, Zhou C. WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1. Biochim Biophys Acta - Molecular Cell Research. 2009,1793(2):300-11.

12.Li T, Li Y, Jia Z, Chen P, Ma K, Zhou C. Carboxyl terminus of Nkx2.5 impairs its interaction with p300. J Mol Biol.2007, 370(5):976-992.